A General Factor of Brain White Matter Integrity Predicts Information Processing Speed in Healthy Older People

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A general factor of brain white matter integrity predicts information processing speed in healthy older people.

Human white matter integrity has been related to information processing speed, but it is unknown whether impaired integrity results from localized processes or is a general property shared across white matter tracts. Based on diffusion MRI scans of 132 healthy individuals with a narrow age range around 72 years, the integrity of eight major white matter tracts was quantified using probabilistic...

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Explorer Brain white matter integrity and cortisol in older men

Elevated glucocorticoid (GC) levels are hypothesized to be deleterious to some brain regions, including white matter (WM). Older age is accompanied by increased between-participant variation in GC levels, yet relationships between WM integrity and cortisol levels in older humans are underexplored. Moreover, it is unclear whether GC-WM associations might be general or pathway specific. We analyz...

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Brain White Matter Tract Integrity and Cognitive Abilities in Community-Dwelling Older People: The Lothian Birth

Publisher Rights Statement: © Booth, T., Bastin, M. E., Penke, L., Munoz-Maniega, S., Murray, C., Royle, N. A., Gow, A. J., Corley, J., Henderson, R. D., Hernández, M. D. C. V., Starr, J. M., Wardlaw, J. M., & Deary, I. J. (2013). Brain White Matter Tract Integrity and Cognitive Abilities in Community-Dwelling Older People: The Lothian Birth Cohort, 1936. Neuropsychology, 27(5), 595-607. 10.103...

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Processing speed is considered a key cognitive resource and it has a crucial role in all types of cognitive performance. Some researchers have hypothesised the importance of white matter integrity in the brain for processing speed; however, the relationship at the whole-brain level between white matter volume (WMV) and processing speed relevant to the modality or problem used in the task has ne...

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ژورنال

عنوان ژورنال: Journal of Neuroscience

سال: 2010

ISSN: 0270-6474,1529-2401

DOI: 10.1523/jneurosci.1553-10.2010